Editorial: Hybrid Biomolecular Modeling

Hybrid Modeling and Simulation of Biomolecular Networks

In a biological cell, cellular functions and the genetic regulatory apparatus are implemented and controlled by a network of chemical reactions in which regulatory proteins can control genes that produce other regulators, which in turn control other genes. Further, the feedback pathways appear to incorporate switches that result in changes in the dynamic behavior of the cell. This paper describ...

Foundations of Biomolecular Modeling

The 2013 Nobel Prize in Chemistry has been awarded to Martin Karplus, Michael Levitt, and Arieh Warshel for "development of multiscale models for complex chemical systems." The honored work from the 1970s has provided a foundation for the widespread activities today in modeling organic and biomolecular systems.

Editorial: Hybrid Solutions for the Modeling of Complex Environmental Systems

Modeling of biomolecular interactions

In the beginning of the 21st century, one of the main goals of society is to increase the quality of life and maintaining the full performance and physical activity throughout the whole lifetime. This leads to extremely rapid development of all areas of human knowledge related to the study of living matter and to fast application of the obtained results for society benefit. Special attention is...

Modeling and analyzing biomolecular networks

The authors argue for the need to model and analyze biological networks at molecular and cellular levels. They propose a computational toolbox for biologists. Central to their approach is the paradigm of hybrid models in which discrete events are combined with continuous differential equations to capture switching behavior. Disciplines Engineering | Mechanical Engineering Comments Suggested Cit...